Opportunity Information: Apply for PAR 17 039
The Comparative Biology of Neurodegeneration (R21) funding opportunity (PAR-17-039) is a National Institutes of Health program from the Department of Health and Human Services that supports exploratory, early-stage research looking at neurodegeneration through a comparative biology lens. The central idea is to study how different animal species handle biological stressors and cellular damage in ways that could either contribute to the development of Alzheimers disease and related neurodegenerative conditions or, importantly, provide resilience against them. Instead of focusing on a single traditional model system, the program encourages researchers to compare species that may differ widely in lifespan, brain aging patterns, stress tolerance, regenerative capacity, or susceptibility to protein aggregation, with the goal of identifying protective mechanisms that might be translated into human health insights.
The scientific scope emphasizes cellular physiology pathways that are strongly tied to neurodegenerative disease risk and progression. Examples highlighted in the opportunity include adaptation to stress, macromolecular damage (such as damage to DNA, proteins, and lipids), proteostasis (the systems that maintain proper protein folding, trafficking, and clearance), and stem cell function and regeneration. Projects might examine how certain species maintain neural function despite high oxidative stress, how they prevent or tolerate the buildup of damaged proteins, or how they repair or replace vulnerable cell populations over time. The R21 mechanism is designed for exploratory work, so it is generally well-suited to high-risk, high-reward ideas, pilot datasets, testing new comparative approaches, or establishing whether unusual species traits can be interrogated with feasible experimental strategies.
From an administrative standpoint, this is a discretionary grant using the NIH R21 exploratory/developmental award mechanism, and it falls under the health funding activity category (CFDA 93.866). The award ceiling listed is $200,000, and the opportunity anticipated around 10 awards, reflecting a relatively selective competition. The original posting date was October 27, 2016, with an original closing date of January 7, 2020, meaning the program as listed corresponds to that time window and applicants would typically need to check whether the announcement has been reissued or replaced by a newer version before preparing a submission.
Eligibility is broad and includes many types of organizations that commonly apply to NIH funding. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding institutions of higher education in those categories), for-profit organizations other than small businesses, small businesses, and a wide range of government entities such as state, county, city or township governments, special district governments, and independent school districts. It also includes Native American tribal governments (federally recognized), tribal organizations that are not federally recognized as governments, and public housing authorities/Indian housing authorities, along with other entities as described in the announcement’s additional eligibility language.
Overall, the opportunity is aimed at catalyzing new comparative research directions that could clarify why some species show reduced vulnerability to neurodegenerative processes or possess stronger compensatory biology. By focusing on conserved and divergent responses to cellular stress, damage accumulation, protein quality control, and regenerative biology, the program seeks to uncover mechanisms that may inform future therapeutic strategies, biomarkers, or prevention concepts for Alzheimers disease and other neurodegenerative disorders.Apply for PAR 17 039
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Comparative Biology of Neurodegeneration (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on Oct 27, 2016.
- Applicants must submit their applications by Jan 07, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- The number of recipients for this funding is limited to 10 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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